IMPROVEMENT OF SOLUBILITY OF CEFIXIME AND OMEPRAZOLE BY SOLID DISPERSION AND SLUGGING METHOD

In fact, it has been estimated that 40% of new chemical entities currently being discovered are poorly watersoluble. Unfortunately, many of these potential drugs area bandoned in the early stages of development due to solubility concerns. Cefixime as per BCS classification is a class IV drug with poor solubility and poor permeability. Poor solubility of drugs leads to poor absorption and hence poor bioavailability. Omeprazole as per BCS classification is a class II drug with poor solubility and good permeability. Methods, such as salt formation, complexation with cyclodextrins, solubilization of drugs in solvent(s), and particle size reduction have also been utilized to improve the dissolution properties of poorly water-soluble drugs. Bioavailability of a drug can be increased by increasing the solubility of a drug. The % increase in saturation solubility with PVPK- 30 and urea was higher than other polymers and techniques. This shows that solid dispersion using solvent evaporation technique gives a better solubility of drug when compared to other techniques. This might be due to the better solubilization effect of drug and polymer with solvent over PEG-6000 and slugging method. Slugging method is next best alternative for solubilization of drug. Key Words: Omeprazole, Cefixime, PEG-6000, PVPK-30.