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Vitamin D supplementation attenuated carageenan-induced paw edema and formalin-induced nociception in indomethacin-treated rats

Journal: International Journal of Basic & Clinical Pharmacology (Vol.3, No. 1)

Publication Date:

Authors : ;

Page : 206-210

Keywords : Vitamin D; antiinflammatory; antinociceptive; indomethacin; supplementation;

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Background: This work evaluated the effect of vitamin D supplementation on carrageenan-induced paw edema and formalin-induced nociception in indomethacin treated rats. Methods: Rats were grouped into six (A ? F) of 5 each. Groups (C ? F) were pretreated for 14 days with vitamin D; 250, 500, 1000 and 1000 iu/day respectively. On day 15, they were treated as follows: group A (10 ml/kg distilled water), B; (10 mg/kg indomethacin), C ? E; (10 mg/kg indomethacin) F (1000 iu/day vitamin D alone). One hour later 50μl 1% carrageenan or 25μl 5% formalin was injected into the sub-plantal surface of left hind paw. For carageenan-induced paw edema, paw sizes were measured 1 h later, then every hour for 5h. For formalin-induced nociception, number of paw licking/lifting was counted for each rat from 0 ? 5 min (first phase) and 25 ? 30 min (second phase) post-formalin injection.

Last modified: 2014-02-08 13:47:52