INDICATORS OF PRO- AND ANTIOXIDANT SYSTEM IN ACUTE INTESTINAL INFECTIONS IN CHILDREN

Background. The endogenous glutathione system in the human body provides antioxidant homeostasis that protects biological membranes from various damaging factors. The purpose of research: to establish the role of reduced glutathione (GSH) as a prognostic criterion of acute kidney injury (AKI) in children with acute intestinal infections (AIIs). Material and methods. A total of 147 children (mean age 3.5 years) with AIIs were divided into 3 groups according to the severity of acute kidney injury: the 1st – no acute kidney injury, the 2nd – transient disturbances, the 3rd – severe acute kidney injury. Results. Statistically significant differences in GSH levels in the compared groups (p<0.05) were established. The lowest values were observed in the third group of patients with severe acute kidney injury. Conclusion. Monitoring of blood GSH levels in children with AIIs can be used as a diagnostic criterion of acute kidney injury. Сhildren with AIIs having a low content of GSH in the blood are recommended to include antioxidants into initial therapy.