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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.04, No. 07)

Publication Date:

Authors : ; ; ;

Page : 2164-2169

Keywords : Galantamine; Fast Dissolving Films (FDFs); KollicoatIR; Super Disintegrants.;

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In the present work efforts have been made to prepare the fast dissolving films of Galantamine using water soluble semi synthetic polymers such as HPMC 3cps, Na CMC and KollicoatIR using plasticizer by means of sodium starch glycolate, super-disintegrants by using the solvent casting method. By comparing with the marketed tablet, the FDFs formulated by means of using superdisintegrant showed fast release for quicker onset of action within minutes. The prepared films were evaluated for physico-chemical properties and invitro release kinetics. The selected formulations produced clear, uniform, flexible and desired thickness. The thickness of the film varied from 0.27 mm - 0.68 mm, folding endurance varied from 10 - 20, surface pH varied from 6 - 7. The DSC thermogram showed endothermic peak for optimized formulation, within the limits of pure drug melting point range. The prepared FDFs of Galantamine using different polymers showed good promising results for the evaluated parameters. Based on the rate of drug release, among all the formulations, the formulation F10 containing KollicoatIR was concluded as optimized formulation, which showed 84.01% of drug release within 10 minutes. Key Words: Galantamine, Fast Dissolving Films (FDFs), KollicoatIR, Super Disintegrants.

Last modified: 2017-08-17 21:30:43