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Journal: Indian Drugs (Vol.53, No. 2)

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Page : 62-64

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Lamotrigine is currently available as a tablet which is administered 2-3 times per day as divided doses of 25-600 mg. Oral liquid formulations with additional sustained release properties are always preferred for pediatric, geriatric even dysphagic patients, due to their ease of administration and patient compliance even at the time of epileptic attack. Hence, polymeric micelle formulation of lamotrigine and safranol niosomal nasal formulation were studied. Polymeric micelles containing lamotrigine were prepared by direct dissolution technique using block copolymer (Pluronic L81, Pluronic F68) in combination (1:1) ratio. Niosomes containing safranal were prepared by modified ether injection technique using non-ionic surfactants (Span 80 and Tween 20 & 80), gelucire 44/50, pluronic f-127 and cholesterol at different ratios. In this test, strychnine (4 mg/kg) was injected to the animal subcutaneously (s.c.) beneath the loose folds of neck skin. Fifteen minutes post administration of lamotrigine and safranal administration by intravenous route. Animals were observed for 10 min for occurrence and onset on various seizures. Latencies were noted in seconds. The present study is to evaluate anticonvulsant activity of lamotrigine (LTG) polymeric miceller formulation and safranal niosomal formulation on strychnine induced convulsions in mice. Vehicle failed to protect the mice from generalized clonic-tonic convulsions induced by strychnine. Lamotrigine significantly delay the onset of myoclonic, clonic and tonic extensor by all three routes i.e. nasal, intravenous and oral as compared to vehicle group. Effect of lamotrigine by nasal route is similar to the effect by intravenous route. Lamotrigine by nasal and intravenous route have shown more effect when given by oral route. Lamotrigine and safranal significantly delay the onset of myoclonic, clonic and tonic extensor by I.V. route as compared to vehicle group.

Last modified: 2017-08-23 15:26:42