Q- ABSORPTION RA TIO AND SIMULTANEOUS EQ UATION SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF FENBENDAZOLE AND NICLOSAMIDE IN PURE DRUG AND PHARMACEUTICAL FORMULATIONS

Two simple, accurate, sensitive and economical spectrophotometric methods have been developed and subsequently validated for determination of fenbendazole (FEN) and niclosamide (NIC) in bulk and pharmaceutical formulation. For the simultaneous equation method, the estimation of FEN and NIC was carried out at 227nm (λmax of FEN) and 332nm (λmax of NIC), respectively. For Q - absorption ratio method, estimation of FEN was carried out at 227nm (λmax of FEN) and of NIC at 306 nm (isobestic point of both drugs). Calibration curves of FEN and NIC were found to be linear in the concentration ranges of 3-9