HISTOPATHOLOGICAL INVESTIGATION ON HIGH FAT DIET INDUCED DEFORMATIES IN RAT LIVER AND HEART: ROLE OF RHINACANTHUS NASUTUS (L) KURZ METHANOLIC LEAF EXTRACT IN ALLEVIATION OF TISSUE DEFECTS

Rhinacanthus nasutus (L) belongs to Acanthaceae family, widely distributed in some parts of sub-continent, in the region of Southeast Asia and China, and it is cultivated particularly as a medicinal plant which has been used in treatment and prevention of diverse diseases as folklore medicine. Different parts of R.nasutus are also used in traditional medicine for the treatment of eczema, pulmonary tuberculosis, herpes, hepatitis, diabetes, hypertension and skin diseases. The aim of present study was to analyze the histological changes of rat liver and heart by inducing high fat diet and HFD+RN active principle extract in dosage and time dependent manner. The results has indicated that HFD+RN showed infiltration, recovered sinusoids space and increased size of hepatocytes, Orlistat+High fat diet(OL+HFD) treatment, as control suppressed formation of lipid droplets and necrosis, when compared with high-fat diet fed rats and in heart the HFD group has caused the necrosis due to excess feed and inflammation. The OL+hfd treated group found to contain damage to cardic myocytes and interstitium. The present study conclude that the high fat diet+ R.nasutus (HFD+RN) rat group showed recovery from the damage of infiltration, sinusoids and necrosis in liver and heart tissues. Key Words: Rhinacanthus nasutus, Liver, Heart, Histology, High Fat Diet