SYNTHESIS OF SOME NEW PYRIMIDINE HETEROCYCLE BEARING NUCLEUS AS POTENT ANTICANCER AGENTS

A series of pyrimidine derivatives were synthesized by the reaction of substituted aromatic aldehyde with substituted acetophenones in alkaline medium to form chalcones (1). further treatment of these derivatives with thiourea in alkaline medium afforded 4,6-disubstituted pyrimidine-2-thiones (2a1-a14). All the synthesized compounds were confirmed by TLC and melting point. The structures of the synthesized compound have been established on the basis of IR, 1H NMR, EIMS spectral analysis and elemental analysis. All the compounds were screened for their anticancer activity against A549 cell lines by SRB assay and compounds (2a10 and a12-a14) displayed promising anticancer activity with CTC50 value 133, 127, 115 and 118μg/mL, respectively.