ANTI-OBESITY ACTIVITY OF METHANOLIC EXTRACT OF TRICHOLEPIS GLABERRIMA

Obesity is very serious and concerned problem these days. Despite availability of many drugs in market to treat obesity, no single drug is ideal for treating all sorts of problems caused by obesity. The obesity models available for inducing obesity are by using chemicals and high fat diet. Wistar albino rats were used to study anti-obesity activity of methanolic extract of Tricholepisglaberrima plant aerial parts at doses 100 mg/kg p.o. and 200 mg/kg p.o. against the standard orlistat 50 mg/kg p.o. in models of anti-obesity activity viz. High fat induced obesity, Monosodium glutamate induced obesity model. The induction of obesity is done by diet (20 grams/animal/day) and Monosodium glutamate (oral). The study period is 28 days for both models. In both models, the plant showed anti-obesity activity significantly at a dose of 100mg/kg and 200 mg/kgp.o. by reducing the body weight, fat pads weight, total cholesterol, triglycerides, LDL, VLDL, biomarkers enzymes like SGOT, SGPT and ALP, whereas significant increase in HDL levels was observed. Further multiple dose preclinical studies and clinical studies have to be carried out for proving for human obesity treatment. Key words: Tricholepisglaberrima, anti-obesity, Cholesterol, HFD, MSG