The role of microbial factors and defensins in the mechanisms of development of eczematous cheilitis

The subject of the study was a study of mechanisms for the development of allergic damage to the lips and establishing the role of microbial factors and antimicrobial peptides of the first line of immunological defense (α-defensins) in patients with microbial and seborrhoeic eczema, as well as contact eczematous cheilitis. With the help of modern methods of statistical processing of materials, interrelations between the results of laboratory and clinical examination of patients were established. The most frequent microbial factors that contribute to the development of eczematics in patients (including streptoderma, conglobata and abscessed acne), as well as chemical factors that lead to the development of a contact eczematous process (including - with the use of cosmetic facial skin care products and lips). In all patients, the level of peripheral blood content of α-defensins decreased reliably; between the changes in the laboratory indicators studied and the changes in clinical status from the skin and the gastrointestinal tract, significant correlation links were established. The results dictate the need to make adjustments to plans for examination, treatment and prevention of patients with allergic lesions of the lips.