DESIGN AND INVITRO CHARACTERIZATION OF GASRO RETENTIVE MUCOADHESIVE FLOATING TABLETS OF METFORMIN HCL

In the present research work gastro retentive mucoadhesive floating formulation of Metformin was developed by using various hydrophilic polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent accrual and bioadhesive polymer carbopol concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various polymers. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations prepared with HPMC K15M retarded the drug release up to 12 hours in the concentration of 220mg (F10).The formulations prepared with HPMC K4M and HPMC K100M released drug less than 12 hours. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed zero order kinetics of drug release. Key words: Gastro retentive, Mucoadhesive, Floating, HPMC etc.