Antimicrobial susceptibility pattern of Gram negative bacterial isolates from cases of Ventilator Associated Pneumonia in a tertiary care institute

Introduction: Ventilator Associated Pneumonia (VAP) is the most commonly encountered health care associated infection among mechanically ventilated patients, which in turn contributed for raised morbidity, mortality and prolonged hospital stay. Early onset VAP is more common in comparison to late onset VAP. Materials and Method: This study was conducted in a tertiary care teaching hospital for a period of one and half year ranging from January 2013 to June 2014. Clinical Pulmonary Infection score (CPIS) of more than six was used for the clinical diagnosis of VAP and only culture proven cases, out of clinically suspected were further evaluated. Results: Overall rate of VAP was 19.87 per 1000 device days with (0.40) device utilization ratio. Among Gram negative bacterial isolates from VAP, Pseudomonas aeruginosa (50%) was the leading isolate followed by Acinetobacter baumanii (17.64%) and E. coli (14.70%). Pseudomonas aeruginosa exhibited (47.05%) resistance to ciprofloxacin and gentamicin followed by (41.17%) to cefepime, (35.29%) to piperacillin (17.64%) to Amikacin. Acinetobacter baumanii exhibited (100%) resistance to amoxycillin+clavulanic, piperacillin, piperacillin+ Tazobactum, followed by (83.33%) to amikacin. Conclusion: Continuous surveillance data of Ventilator Associated Pneumonia will be helpful in reducing the number of cases of VAP and thus in reducing the associated adverse outcomes.