Xanthine oxidase -oxidase stress marker in acute MI patient: a study at a teaching hospital in Telangana

Introduction: Despite impressive strides in diagnosis and management over the past three decades, acute myocardial infarction (AMI) continues to be a major public health problem in the industrialized world and is becoming an increasingly important problem in developing countries. Xanthine oxidase in ischemic conditions of the heart may play an important role in generating free radical mediated damage. Aim of the Study: To measure the levels of xanthine oxidase activity in myocardial infarction patients. Materials and Method: The study was conducted from the month of June 2011 to May 2012, at MGM Hospital, Warangal blood samples of 30 patients diagnosed as acute myocardial infarction were collected and subjected to plasma xanthine oxidase activity. Results: 60% of AMI patients belonged to 51-60 years age group. There was significant increase in mean values in Xanthine oxidase activity levels in (p < 0.001) in the study group as compared to controls. Conclusion: Xanthine oxidase is good markers in identifying AMI. They all can be used together as multiple markers to increase their efficiency as markers of AMI. The AST & LDH though exhibited good sensitivity, lack specificity. Hence they should not be used as individual markers.