DEVELOPMENT AND INVITRO EVALUATION OF MIGLITOL INSITU GEL FOR MANAGEMENT OF NONINSULIN DEPENDENT DIABETES MELLITUS

The objective of the present investigation was to develop an effective insitu proliposomal gel formulations for treatment of Non-insulin dependent diabetes.The proliposomes containing Miglitol was prepared by film deposition on carrier method using vacuum rotary evaporator. The optimization of Miglitol proliposomes was done by preparing the different formulations by varying the concentration of mannitol, phosphatidyl choline and cholesterol. Formulation prepared by using 50mg of miglitol, 1g mannitol, Phosphatidyl choline 150mg, Cholesterol 100 mg, chloroform 6ml and methanol 4ml was selected as optimized formulation. The cumulative amount of drug release of various proliposomal formulations and conventional Miglitol gel in 7.4 pH after 16hrs showed 80.5% and 95.1% for conventional gel. The drug release followed Peppas model.which confirms that release of proliposomal formulation was Fickian diffusion. Key Words: Miglitol proliposomal gel, Mannitol, cholesterol, phosphatidyl choline