GLUCOSE TOLERANCE IN PATIENTS WITH CHRONIC LIVER DISEASE

Objective: To evaluate the glucose tolerance in patients with chronic liver disease. Patients and Methods: This cross sectional study of six months was conducted at tertiary care hospital and studied the demographical and clinical manifestations and OGTT in thirty patients with chronic liver disease. The inclusion criteria were the patients diagnosed with chronic liver disease between the age group 12-60 years of either gender. All the relevant patients should have detail history, clinical examination and advised fasting and random blood sugar level and the oral glucose tolerance test accordingly while the response of test was also observed. The frequency and percentages was calculated while the numerical statistics were used to compute mean ±SD. Results: During six months study period total thirty patients with chronic liver diseases were recruited, enrolled and evaluate for the glycemic status. The mean age ±SD for whole population was 47.53±5.82 years, of thirty individuals 17 (56.6%) were males and 13 (43.3%) were females. The common etiologies detected for chronic liver disease were Hepatitis B (30%), hepatitis C (33.3%), hepatitis B & C (10%), alcoholic liver disease (10%) and hepatoma (10%). The OGTT response revealed as normal 16 (53.3%), impaired glucose tolerance 08 (26.6%) and diabetes mellitus 06 (20%) respectively. Conclusion: The positive correlation between chronic liver disease and glucose tolerance. Thus, the impaired glucose response is most common in liver cirrhosis. Keywords: Oral glucose tolerance test, chronic liver disease, Liver cirrhosis, impaired glucose tolerance and Diabetes Mellitus