Preventive Role of Amygdalin in Squamous Cell Carcinoma Induced in Hamsters

Oral squamous cell carcinoma (OSCC) represents 95% of all forms of head and neck cancer, In recent years the development of antitumor drugs has been gradually transformed from cytotoxic drugs to develop new targeted drugs with low toxicity and high specificity. Amygdalin is extracted from bitter apricot kernels and has been used for the treatment of many cancers. Amygdalin is considered as a natural product that owns antitumor activity, less side effects and it is widely sourced. We investigate in this study the preventive role of amygdalin in squamous cell carcinoma induced in the buccal pouch of hamsters, by detecting its correlation to the the main proteins in cell cycle and apoptosis(P53 and BCL2, respectively).