COMPARATIVE CARDIOTONIC ACTIVITY OF NEEM LEAF EXTRACT WITH DIGOXIN ON ISOLATED FROG HEART

Azadirachta indica has been used medicinally throughout history by many different cultures. Many compounds have been found in the exudates of the Azadirachta indica plant that have been used medically by humans. Present study was carried out to determine the cardiotonic activity by using infusion of Neem leafextractwith different dilutions & compared with cardiotonic activity of digoxin‐the life saving cardiotonic. The a ctivity was tested by using isolated frog heart assembly. The present preliminary studies confirm the better cardioton ic activity of Neem leaf extract than digoxin. Further studies can confirm the reduced toxicity & this will be the advantage of Neem leaf extract over digitalis. Thus,in future it will be interesting to isolate the active chemical constituents are responsible for the cardiotonic activity. Keywords: Cardiotonic activity, Digoxin, Neem leaf extract, isolated frog heart.