Different Performance and Prognosis for a Familial Case of Sarcoidosis in China: Novel Insight from Clinical Practice

Sarcoidosis is a common multi-system disease characterized histolopathologically by the formation of non-caseating granulomas in the affected tissue. Hereditary susceptibility to sarcoidosis is suggested by ethnic preponderance, familial clustering, and multigenerational involvement, but the genetics of sarcoidosis do not be adequately confirmed, so do the living environment, especially in china. This report presents a 55-year-old woman with blood-tinged sputum and exertional dyspnea. The clinical, laboratory examination and pathology revealed that the patient had sarcoidosis (stage II). Appropriate therapy was administered, and the patient symptom and sign were improved significantly. Her son was a patient with pulmonary sarcoidosis (stage II) contemporarily, however, no symptom and sign were revealed and self-healing happened. Her mother was a patient with pulmonary fibrosis which caused by sarcoidosis in family history, although appropriate therapy was given, but the patient symptom and sign were not improved significantly, her mother died because of serious lung fibrosis and combined infection. Nothing living environment and infection factors were found. There were different performance and prognosis for a Chinese family case of genetic predisposition sarcoidosis and the same disease remain needs individualized treatment.