FORMULATION AND EVALUATION OF CLINDAMYCIN PHOSPHATE EMULGEL

Introduction: Topical drug administration is simplest and easiest route of localized drug delivery anywhere in the body by routes as ophthalmic, rectal, vaginal and skin. These are applied as wide spectrum of preparations in case of both cosmetic and dermatological, to the healthy or diseased skin. Drugs are administered topically for their action at the site of application or for systemic effects. Clindamycin is a lincosamide antibiotic. It is usually used to treat infections with anaerobic bacteria, but can also be used to treat some protozoal diseases, such as malaria. It is a common topical treatment for acne and can be useful against some methicillin-resistant Staphylococcus aureus (MRSA) infections. Objective and aim: The aim of present study was to develop an emulgel formulation of clindamycin phosphate using Carbopol 934 or HPMC 2930 as a gelling agent. The influence of the type of gelling agent and the concentration of both the oil phase and emulsifying agent on the release of the drug and its microbial activity were investigate using 2 3 factorial design in addition, rheological properties were also evaluated. Conclusion: The present work is to develop Clindamycin emulgel adaptable topical drug delivery systems which provide protection against oxidation, fast absorption, prolonged release and enables reduction in dose and evaluate the emulgel using an ideal topical drug candidate of Clindamycin by suitable method with its release. Keywords: Clindamycin emulgel, Formulation, Evaluation.