ANALGESICS AND ANTIBACTERIAL ACTIVITIES OF BERBERIS LYCIUM ROOTS COLLECTED FROM DISTRICT ZIARAT, BALOCHISTAN

Berberis lycium (berberidaecae) is a conventional medicinal plant of Balochistan province in Pakistan. It is traditionally used as an antipyretic, anti inflammatory, anti hypercholesterolemia, antidiabetic and for wound healing. This present study has evaluated the pharmacological (analgesic) and antibacterial activities of the crude ethanoic extract of the roots of Berberis lyceum. Disc diffusion and Well methods were used for antibacterial activities where as acetic acid induced Writhing and Formalin tests were used to determine analgesic activities. Berberis lycium crude extracts showed significant antibacterial activity on Gram +ive anaerobe Clostridium perfringens and Gram -ive Escherichia coli. However, it did not show analgesic activity in albino mice at both 250 and 500 mg/kg oral doses. It is therefore concluded that B. Lycium has a very positive effect on both Clostridium perfringens and Escherichia coli. Keywords: Analgesics, antibacterial, Berberis Lycium, Ziarat, Balochistan