The middle mass molecules and oligopeptides content in rat blood and tissues under the acid esophagus burn conditions

The burn was accompanied by prolonged protein metabolism disorders, which led to the pathological changes in the various organs and systems functioning. The main diagnostic criterion of the acid burn severity is the total protein and albumin levels. These parameters are the major biochemical blood serum indicators that can characterize the functional state of the organism and to assess the degree of metabolic disorders under the studied pathology. The level of these indicators was the most declined at the 1 st and 7th days after acid treatment comparing with the control values. The endogenous intoxication after the acid burns the esophagus 2 degrees in immature rats modelling is shown. The markers of endogenous intoxication (oligopeptides and middle mass molecules) in the blood serum of immature rats were increased on the 1st day of experiment. acid burns the esophagus. The above mentioned parameters of endogenous intoxication were measured in liver, spleen, mucosa of the esophagus rat cell homogenates and they had the highest level for 15, 21 days under the conditions of the second-degree acid esophagus burn. The level of the middle mass molecules and oligopeptides varied depending on the metabolic state of the organism and was prognostic criterion of metabolic disorders. This substances accumulation is not only a marker of endointoxication, they could further reinforce the pathological processes acquiring the secondary toxic role and affecting the livelihoods of all systems and organs. In this regard, the searching of the agents having anti-toxic properties is exceedingly important for the burn patients' treatment.