Bilosomes Based Drug Delivery System

Vesicular carrier systems (liposomes & niosomes) are one of the potential candidates for vaccine delivery by the oral route. But its instability in gastrointestinal environment makes it less applicable to be used for the purpose of oral immunization. This necessitates larger and more frequent doses of antigen for vaccination. Drug delivery system overcomes which a lipid vesicle is containing bile salts (bilosome), which prevents antigen degradation and enhances mucosal penetration. New generation bilosomes are more stable in gastrointestinal tract. This review is sharply focused on comparative overview of liposomes, niosomes and bilosomes. Biolosomes benefits, future perspective, market application characterization and stability of bilosomes.