FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET QUETIAPINE FUMARATE BY USING NATURAL POLYMER

The purpose of present study was to develop once a day sustained release matrix tablet of Quetiapine Fumarate by using natural polymer viz. Xanthan gum and isolated fenugreek mucilage. Varying ratios of drug and polymer like were selected for sustained release tablet by using direct compression method. After fixing the ratio of drug and polymer for Sustain the release of drug up to desired time, the release rates were modulated by combination of two different rates controlling material and triple mixture of two different rate controlling material. After evaluation of physical properties of tablet, the in vitro release study was performed in 0.1 N HCl pH 1.2 for 2 hrs and in phosphate buffer pH 6.8 up to 12 hrs. The effect of polymer concentration and polymer blend concentration were studied. Dissolution data was analyzed by Higuchi expression. It was observed that matrix tablets contained polymer blend of Xanthan gum and isolated fenugreek mucilage were successfully sustained the release of drug up to 12 hrs. Among all the formulations, formulation P3 which contains 15 % Xanthan gum and % 25 of fenugreek mucilage release the drug which follow Higuchi kinetics via, diffusion and erosion and the release profile of formulation P3 was comparable with the prepared batch products. Key words: Sustained release, Xanthan gum, Fenugreek mucilage, Quetiapine Fumarate, phosphate buffer.