ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login


Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.05, No. 01)

Publication Date:

Authors : ;

Page : 483-491

Keywords : Sedimentation rate; Ion exchange resin; Stability; Ciprofloxacin; Indion 234; Acacia; Tragacanth; Sodium carboxy methyl cellulose.;

Source : Downloadexternal Find it from : Google Scholarexternal


Taste masking and development of palatable dosage forms of bitter drugs constitutes the objective of many a research project in the field of pharmaceutical technology. Taste is an important factor in the development of dosage form. The problem of bitter and obnoxious taste of drug in pediatric patient can create a bad psychological effect on mind. The purpose of this research was to mask the intensely bitter taste of Ciprofloxacin is a broad spectrum antibiotic. It is extremely bitter taste resulting in poor patient's compliance. The aim of present work was to prepare drug resin complex (DRC) using ion exchange resin (Indion 234) for taste masking and formulate oral reconstituable dry syrup of DRC. DRC was evaluated for effect of variables like drug resin ratio, pH, temperature, soaking time of resin and stirring time reconstituable dry syrup was prepared by using xanthan gum and microcrystalline cellulose as suspending agent formulated recostituable dry syrup was evaluated for before reconstitution parameters like flow properties, particle size and drug content and after reconstitution parameter like sedimentation rate redispercibility particle size, viscosity, pH and drug content. Formulated ciprofloxacin reconstituable dry syrup has acceptable sedimentation properties. In evaluating period of 14 days no significant change was observed in pH, viscosity, particle size and drug content.From the results it concluded that effective taste masking of ciprofloxacin was achieve using indion 234 and successfully evaluated in reconstituable dry syrup. Key Words: Sedimentation rate, Ion exchange resin, Stability, Ciprofloxacin, Indion 234, Acacia, Tragacanth, Sodium carboxy methyl cellulose.

Last modified: 2018-01-28 03:18:18