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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.05, No. 01)

Publication Date:

Authors : ;

Page : 769-778

Keywords : Lamotrizine; UV-Visibile spectrophotometer; superdisintegrants; crospovidone;

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The aim of the present study was to develop and optimize oral disintegrating tablets of model drug (Lamotrizine) to give quick onset of action by rapidly disintegrating in a few seconds without the need of water with better patient compliance. In such cases, bioavailability of drug is significantly greater and adverse event is reduced than those observed from conventional tablet dosage form. By performing compatibility studies by IR spectrophotometry, no interaction was confirmed. Oral disintegrating tablets were formulated by direct compression method and evaluated by UV-Visibile spectrophotometer. Standard calibration curve prepared to determine the drug content in the prepared tablets. Prior to compression, the blend of drug and excipients were evaluated for flow properties such as Angle of repose, Bulk density, Tapped density, % Compressibility, and Hausner ratio. All the formulation showed excellentproperties. Oral disintegrating tablets were prepared by direct compression technique using CADMACH 16 station tablet punching machine, equipped with round flat punches of 8 mm diameter. Post compression evaluation of prepared oral disintegrating tablets were carried out with the help of different pharmacopoeial and non-pharmacopoeial (industry specified) tests. The shape and color of all the formulations were found to be circular and white in color. The thickness was found to be uniform in specific formulations. The hardness and friability are also within the permitted limits. Dissolution of tablets was carried out. The crospovidone used formulation gave the more dissolution profile compared to other superdisintegrants. Keywords: Lamotrizine, UV-Visibile spectrophotometer , superdisintegrants, crospovidone

Last modified: 2018-02-19 02:39:54