FORMULATION AND EVALUATION OF LEVITIRACETAM MATRIX TABLETS

For many years the treatment of acute or chronic sicknesses were carried out normally via the transport of medication to sufferers through diverse pharmaceutical forms encompass pills, pills, creams, suppositories, drinks, ointments, aerosols and injectables. The kinds conventional oral drug delivery systems are regarded to provide delivery of the drug. Therefore to reap as well as to hold the drug awareness within the range of healing effectiveness required for the treatment. Levetiracetam matrix tablets were prepared by using different viscosity grades of Polyethylene oxides such as PEO WSR 301, PEO Coagulant and PEO 303. The matrix tablets were prepared by direct compression method. The matrix tablet formulation L-8 and L-10 which releases all the drugs in 12 hours were selected for the study of accelerated stability. All levetiracetam matrix tablets with PEO WSR 301 (L1 to L-4) were evaluated The hardness of the tablets is in the range of 13.1-14 kg/cm2. The friability below 1% indicates clearly the good mechanical resistance of the preparations of tablets. Testing of the prepared matrix tablets was found in the range of 99.1 to 101 % clearly indicates a good uniformity of content. The thickness of the tablets is in the range of 6.18 to 6.28 mm. The weight variation of tablets was within the range and 850 mg were found in all of the tablets. The matrix tablet formulation L-8 and L-10 which releases all the drugs in 12 hours were selected for the study of accelerated stability. DSC and FTIR studies were also performed. Keywords: Controlled release formulations, Levetiracetam matrix tablets, Polyethylene oxides.