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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.05, No. 03)

Publication Date:

Authors : ; ;

Page : 1498-1510

Keywords : Sustained release drug delivery system; Naproxen; invitro drug release; Direct compression method; Di calcium phosphate (DCP);

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The present investigation is concerned with development and evaluation of Sustained release matrix tablets containing Naproxen using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC K100M & HPMC K4M).Preformulation study was done initially which include characterization of polymers, drug identification, FTIR compatibility and result directed for the further course of formulation. The tablets were prepared by direct compression method and evaluation done. Tablets were compressed by tablet compression machine (Karnavati Rimek Mini press1)and evaluated with different parameters like diameter, thickness, average weight, hardness, friability, drug content, kinetic release data. Matrix tablets were compressed without any problem and do not require any change in ratio of excipients in formulation. Results of the present study demonstrated that combination of both polymers and insoluble filler could be successfully employed for formulating sustained release matrix tablets of naproxen. All the formulations containing drug, polymer and DCP as filler sustained the drug release for 24 h. The drug release rate was slower with the tablet containing combination of HPMC K100M and EC polymers compared to with that of combination of two hydrophilic polymers (HPMC-K100M and HPMC-K4M). Wet granulation method was used and found to extend the drug release for 24 h. Hence sustained release drug delivery system of Naproxen is a promising approach as it can lead to decrease in the frequency of administration and ultimately lead to better patient compliance. Keywords: Sustained release drug delivery system, Naproxen, invitro drug release, Direct compression method, Di calcium phosphate (DCP)

Last modified: 2018-03-26 01:26:18