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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.05, No. 04)

Publication Date:

Authors : ;

Page : 2222-2229

Keywords : Central Nervous System Stimulant; Sodium Bicarbonate; Citric Acid; Spray Dried Lactose; Magnesium Carbonate; Sodium Starch Glycolate; Sodium Benzoate; Direct Compression Method.;

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The present study aims at developing a caffeine effervescent tablet formulation for the effective treatment of the central nervous system as it acts central nervous system stimulant of the methylxanthine class. And this dosage form is to provide the patient with the most convenient mode of administration, effervescent tablets will dissolve quickly in water and it releases CO2. And effervescent tablet contains caffeine acts as central nervous system stimulant within seconds of time it will simulate the CNS, onset of action is rapid. Caffeine is a central nervous system stimulant of methyl xanthene class. It is the worlds most widely consumed psychoactive drug. Unlike many other psychoactive substances, it is legal and unregulated in nearly all parts of the world. Caffeine also stimulates certain portions of the autonomic nervous system. So the present work was aimed at formulating effervescent tablet for caffeine, total 6 formulations were developed by using synthetic superdisintigrants like sodium bicarbonate, citric acid, spray dried lactose, magnesium carbonate, sodium starch glycolate, sodium benzoate as superdisintigrants, in a different concentration and prepared by direct compression method and prepared tablets were evaluated for precompression and post-compression parameters after conducting pre-formulation studies. All the parameters were within the pharmacopoeial limits and solution time (3mins 10 sec.), PH of solution (8), Hardness 2.5kg/cm3 , thickness 0.6cm, Average weight of 0.48 in formulation (F2) containing sodium bicarbonate and based on these parameters F2 was selected as best formulation. Key words: Central Nervous System Stimulant, Sodium Bicarbonate, Citric Acid, Spray Dried Lactose, Magnesium Carbonate, Sodium Starch Glycolate, Sodium Benzoate, Direct Compression Method.

Last modified: 2018-04-10 00:28:44