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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.05, No. 04)

Publication Date:

Authors : ;

Page : 2281-2283

Keywords : N’-Substituted-N”-[4-hydroxy-3-(1H-indol-2-yl) phenyldicarbonodithioimide diamide; thioformamide;

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In this work we synthesized a novel series of N'-substituted-N”-[4-hydroxy-3-(1H-indol-2-yl) phenyldicarbonodithioimidediamide by green synthesis parameters from N'-[4-hydroxy-3-(1H-indol-2-yl) phenyl] thiourea and substituted thioformamide. Previously such types of reactions were carried out in acetone medium but we developed new reaction condition in which percentage of acetone was reduced. During synthesis we carried out these reactions in various compositions of ethanol-acetone medium. This method has broad applications due to its efficiency for accelerating a course of organic reactions and increases yields, higher selectivity and lower quantities of byproducts. This method has consequently easier work-up and products obtained are in comparatively pure form. In 70% ethanol-acetone medium we got maximum yields. Justification and confirmations of structure of synthesized compounds were carried by usual elemental analysis, chemical characteristics and spectral studies. Keywords: N'-Substituted-N”-[4-hydroxy-3-(1H-indol-2-yl) phenyldicarbonodithioimide diamide, thioformamide

Last modified: 2018-04-15 02:32:28