Prediction of T-cell epitopes for designing a reverse vaccine against streptococcal bacteria
Journal: Molecular Biology Research Communications (Vol.7, No. 1)Publication Date: 2018-03-01
Authors : Samira Ebrahimi; Hassan Mohabatkar;
Page : 35-41
Keywords : Epitope prediction; Molecular docking; M protein; Streptococcal bacteria; Vaccine design;
Abstract
Streptococcal bacteria are among dangerous human pathogens with major prevalence worldwide. A good vaccine against streptococcal bacteria should have epitopes that confer protection from infection by different streptococcal bacteria types. we aimed was to recognize the most immunogenic and conserved epitopes of streptococcal bacteria, which could be a potential candidate for vaccine development. Nineteen different M proteins of different streptococcal bacteria were chosen and analyzed. Nine-mer epitopes able to simulate both cells mediate and humoral immunity were predicted. Molecular docking was applied in order to measure free binding energy of selected epitopes. Final epitopes were analyzed if they were conserved among different streptococcal bacteria. The identified epitopes require experimental validation for their potential use in peptide vaccines.
Other Latest Articles
- Apoptosis induction in acute promyelocytic leukemia cells through upregulation of CEBPα by miR-182 blockage
- The association between NFKB1 -94ATTG ins/del and NFKB1A -826C/T genetic variations and coronary artery disease risk
- Evaluation of genetic relationship between 15 bamboo species of North-East India based on ISSR marker analysis
- Evaluation of prodynorphin gene polymorphisms and their association with heroin addiction in a sample of the southeast Iranian population
- INFORMATION TECHNOLOGY USAGE: QUANTITATIVE ANALYSIS OF SMARTPHONE SECURITY AWARENESS AND PRACTICES AMONG UNDERGRADUATE STUDENTS IN THE UNITED STATES
Last modified: 2018-04-30 15:23:54