FORMULATION AND INVITRO EVALUATION OF STOMACH SPECIFIC FLOATING MICROSPHERES OF ACELCLOFENAC

The aim of the present work is to study the effect of polymer characteristics on the drug release from hydrogels which were prepared using different polymers (Sodium alginate, Sodium CMC, HPMC K100 and Carbopol) by Ionotropic gelation method. The main objective of the research work is to study the drug and polymer interaction. The formulated hydrogels were characterized for their physico-chemical parameters like swelling ratio, water uptake, gel fraction, percentage yield, drug content, drug entrapment efficiency and size analysis. FTIR studies reveal the drug excipients compatibility. In-vitro drug release studies revealed that the high % drug release for F9 was 98.9% up to 14hrs. Swelling ratio and water uptake by F9 formulation was 12.6± 0.05 and found to be good swelling ratio, high water absorbing ability and high % adherence (77%). Among all formulations, F9 showed controlled drug release up to 14 hrs and considered as ideal formulation. Keywords: Aceclofenac, Hydrogel, Hydroxy Propyl Methyl Cellulose, Sodium alginate, Sodium carboxy Methyl Cellulose, Carbopol, Ionotrpic gelation method.