Effects of Drugs on Electrocardiogram: A Review.

The use of the antiarrhythmic drug is common to treat heart disorder. A computational modeling and simulation are promising tools that could be used to investigate the effects of drugs on cardiac electrophysiology. Aim of this paper is to review the effects of different drugs on cardiac electrophysiology. Effects of sotalol, atenolol, amiodarone, Lidocaine, digoxin, and dofetilide are shown in this paper. These drugs can prolong the QT interval of the electrocardiogram. This effect is important as it is associated with polymorphic ventricular tachycardia and sudden cardiac death. These drugs prolong the QT interval and induce torsade de points on ventricular repolarization. The result shows that the drugs produce the significant increase in QT interval dependent on dose