Clinico-Metabolic profile of Xanthelasma palpebrum

Introduction: Xanthelasma palpebrum (XP) is a disorder of lipid metabolism that usually presents as bilateral and symmetrical, soft velvety papules and plaques around the eyelids. Though various factors contribute to its etiology, a strong association with lipid metabolism is proposed. Usually seen in middle age people, its main concern is cosmetic appearance. Objective: 1. To evaluate the lipid profile, glycemic levels, Body Mass Index (BMI) in patients with Xanthelasma palpebrum. 2. To find the association between parameters like age, sex and comorbid illness with Xanthelasma palpebrum. Materials and Methods: This prospective study included 42 clinically diagnosed patients with Xanthelasma Palpebrarum and 95 subjects in control group with non-inflammatory skin disorders. Levels of serum triglyceride, cholesterol, HDL, LDL, VLDL, blood sugar - fasting and post prandial were determined in all cases along with body mass index and blood pressure. These parameters were compared in both groups and association with XP was analysed. Results and Discussion: In our study, XP was more common in females compared to males. In our study of patients with XP, average fasting blood sugar was 108 gm% and average post prandial blood sugar was 152gm%. Average serum triglyceride levels in patients with XP was 171.4 mg/dl, compared to 108.4 mg/dl in control group with significant p value i.e. 0.001, suggesting strong correlation between XP and serum triglyceride levels. Conclusion: Patients with XP usually visit doctor with cosmetic concern. In most of the cases of XP, serum cholesterol, triglyceride and VLDL levels are deranged. Patients with XP should be evaluated for above parameters and systemic management done along with treatment of XP.