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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.05, No. 05)

Publication Date:

Authors : ;

Page : 3960-3967

Keywords : Naproxen sodium SR tablets; Marketed immediate release tablet; HPMC; LCMS-MS; Bioavailability study;

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The objective of the study was to develop naproxen sodium SR tablets were prepared by direct compression method using hydroxy propyl methyl cellulose (HPMC K 100). To know the effect of polymer concentration invitro study performed it has been observed that as the polymer concentration increases, the drug release rate decreases, and bioavailability study carried out in healthy human subject by administering the developed sustained release and marketed immediate release tablet. The developed naproxen sodium showed confirmed longer time to reach peak concentration than marketed immediate release table, controlled and constant drug delivery system, maintains better plasma concentration than conventional tablet by which it overcome the shortcoming of conservative treatment. The rate and extent of absorption of naproxen sodium SR tablets were higher than the marketed immediate release tablet shows more competent and controlled drug release which would sustain plasma concentration level throughout and produce desired effect. Further evidenced with lower elimination rate and higher half life. Keywords: Naproxen sodium SR tablets, Marketed immediate release tablet, HPMC, LCMS-MS, Bioavailability study

Last modified: 2018-05-22 16:16:12