FORMULATIONANDEVALUATIONOFVORICONAZOLE BUCCAL PATCHES BY USING SELECTED POLYMERS

The aim of the present study is to formulate and evaluate Voriconazole Buccal Patches. Voriconazole is a triazole antifungal drug that is generally used to treat serious, invasive fungal infections. These are generally seen in patients who are immune compromised, and include invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections. In the present study buccal drug delivery of Voriconazole was developed Matrix type of buccal patches was developed by using polymers such as Chitosan and Eudragit S 100. Buccal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as both permeation enhancer and plasticizer. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that there were no interactions between drug and polymers. Formulations were prepared by the varying concentrations polymers ranging from F1-F6, and all the formulations were evaluated for various physical parameters such as Physical appearance, Flatness, Weight variation, Thickness, Folding endurance, Drug content, Moisture uptake, Moisture content. All the results were found to be were found to be within the pharmacoepial limits, invitro drug release studies done by using dialysis membrane. Among all the 06 formulations F4 formulation which contain Eudragit S 100 100mg has shown 95.76% cumulative drug release within 12 hours. For F4 formulation release kinetics were plotted and the Regression coefficient value was found to be high for Korsemeyer Peppas model plot i.e., 0.999. Key words: Voriconazole, Buccal Patches, Chitosan and Eudragit S 100