Apoptosis – Journey of a Cell in Life

Apoptosis is one of the key biological events that has versatile physiological significance starting from the development of an organism, to its differentiation, proliferation and proceeds till the last stage of removal of defective and harmful cells. The cascade of events in apoptosis spans through the entire cellular plethora with morphological and functional changes occurring in all the organelles from nucleus to the cell membrane. Apoptosis and necrosis form the two ends of a spectrum with marked differences in their triggering factors and the sequence of cellular events. The physiological apoptosis becomes pathological if it gets disrupted by mutation resulting in a variety of diseases starting from neurodegenerative disorders to cancer . This review article emphasize the life time journey of cell