Phytochemical Screening And Effect Of Senne-Siamea Methanolic Leave Extract Against Trypanosoma Brucei Brucei In Albino Rat In-Vivo

A two week study was carried out on the anti-trypanosomal activities of the leave extract of senna siamea which was obtained using Soxhlet extraction technique. The in vitro study of anti-trypanosomal activity of the crude extract was conducted using Atawodi S.E 2005 method on albino rats. Two groups of infected rats were treated with 2mgKg of the methanolic extract of the leave of senna siamea resulted in the reduction parasite without any weight lostmaking the extract a potent trypanocidal agent while another group was treated with 1.5mgKg of diminazene aceturate which served as a positive control one group served as a negative control method and the last group was uninfected and untreated. The study also investigated the qualitative phytochemical constituents of the methanolic extract of the leave of Senna siamea and the phytochemicals present are tannin saponins and alkaloid.