Neuropsychiatric Challenges in the Era of Direct-Acting Antivirals: A Case-Report

In the advent of new all-pill treatments for chronic hepatitis C virus infection, there is a myriad of clinical challenges in the management of the psychiatric implications and side effects of such therapies, especially in the patient with major psychiatric disorder, which is a very frequent comorbidity. We describe, for the first time, the clinical case of a patient diagnosed with schizophrenia manifesting clinical decompensation associated with the start of a sofosbuvir-containing treatment regimen. We aim to illustrate and provide a discussion about the clinical challenges and psychiatric management issues posed by a patient with a major mental disorder under a sofosbuvir-containing antiviral regimen for HCV infection.