CLINICAL COURSE OF DEEP VENOUS THROMBOSIS OF LOWER LIMBS IN ACUTE PERIOD WITH UNDERLYING ANTICOAGULANT THERAPY DEPENDING ON CONCENTRATION OF D-DIMERS AND C-REACTIVE PROTEIN

Background. Deep venous thrombosis of the lower limbs (DVTLL) is a significant cause of death and disability of the world population. However, the course and prevalence of DVTLL depending on the concentration of D-dimers and C-reactive proteins (CRP) in the acute period with the underlying treatment are not completely studied. Aim. To study the odd ratio for development of DVTLL, the character of damage and clinical course of thrombosis depending on the concentration of D-dimers and CRP in the acute period with use of anticoagulant therapy (ACT). Materials and methods. The research included 62 patients with DVTLL. The first group included 37 patients with proximal thrombosis (27 men and 10 women), the second group – 25 patients with distal thrombosis (14 men and 11 women). The control group consisted of 74 relatively healthy individuals (45 men and 29 women). On the 1st-3d, 5th-7thand 12th-14thdays of hospitalization, along with standard blood indices, concentration of D-dimers and CRP were determined. Results. In patients in the acute period of proximal and distal DVTLL, the average concentrations of D-dimers and CRP with in 12-14 days were statistically significantly higher than in healthy individuals. The average values of D-dimers and CRP in proximal thrombosis were statistically significantly higher than in distal thrombosis. A moderate correlation relationship was established between concentration of D-dimers and CRP in blood serum on the 5th-7th and 12th14th days of hospitalization in patients with proximal DVTLL, and on the 1st-3d and 12th-14th days in patients with distal thrombosis. Conclusions. Increase in the concentration of D-dimers and CRP in blood serum was associated with increase in OR for development of proximal and distal DVTLL. Increase in the concentration of D-dimers in serum above 500 ng/ml was associated with 36.5- and 35.9-fold increase in OR for development of proximal and distal DVTLL, respectively, and increase in the level of CRP in serum above 10 mg/L – with 16.8- and 8.7- fold increase in OR, respectively. Determination of the concentration of D-dimers and CRP in patients with DVTLL permits to evaluate its course, prognosis and also effectiveness of ACT in the acute period.