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Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.26, No. 2)

Publication Date:

Authors : ;

Page : 305-316

Keywords : P-glycoprotein; ABCB1-protein; inhibitors; plant derived polysaccharides; antineoplastic agents; neuroprotective drugs;

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Inhibition of P-glycoprotein transporter protein (ABCB1-protein, Pgp) is a promising method to increase the effectiveness of pharmacotherapy in different pathologies: neoplastic diseases, epilepsy, cerebral circulation disorders. Pgp is a large transmembrane protein that provides efflux of a wide range of endo- and xenobiotics from cells, and plays a significant role in pharmacokinetics of many medical drugs. Nowadays not a single synthetic inhibitor of the transporter is used in clinical practice due to non-selectivity of action, toxicity and high cost. Medicinal herbal remedies possess different pharmacological and therapeutic effects, rarely cause side effects and are economically accessible. This review presents the results of experiments in which affiliation of the oligo- and polysaccharides to substrates and inhibitors of Pgp was analyzed, and which precondition further studies of other plant derived polysaccharides. Possibilities of using plant derived non-starch polysaccharides in complex therapy of tumors are described, since along with potential inhibition of the transporter, they possess an antitumor effect and can also assist in correction of side effects of cytostatics. The prospects of using plant derived non-starch polysaccharides for improvement of the effectiveness of neuroprotective therapy are presented, because they not only can increase the penetration of neuroprotective drugs across the blood-brain barrier through Pgp inhibition, but also possess their own neuroprotective activity, as well as a number of pharmacological effects that can give a positive result in the complex treatment of brain pathologies. Thus investigations of plant non-starch polysaccharides, their isolation and development of medical drugs on their basis is a promising direction of modern medicine.

Last modified: 2019-01-09 16:14:25