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Clinical Analysis of OncomiR - Therapeutic Targeting of Tumorigenesis and Tumor Disease

Journal: International Journal of Genomics, Proteomics, Metabolomics & Bioinformatics (IJGPMB) (Vol.2, No. 2)

Publication Date:

Authors : ;

Page : 28-35

Keywords : Clinical Sampling; cfmiRNA; Exosome; OncomiR (oncomiRs); miRNA; siRNA; Tumor Prediction; Tumor Prognosis and Biomarkers.;

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A microRNA alteration discovered in clinical patients has largely studied in tumor diseases. Now many profiles of microRNAs alterations have been uncovered to associate with tumor disease and tumorigenesis, and thus the profiles of the miRNA alteration are called as “OncomiR”. Clinically, detecting miRNA profiles from patients has been increasingly applied to predict prognosis and monitor clinical response to treat tumor diseases, classify tumor diseases and study utilizing miRNA profiles to perform RNA therapy for tumor disease and tumorigenesis. The manual aims focus on patient diagnosis, treatment and prognosis prediction by the oncomiR performance and analysis. In order to make clinical physicians easy to understand a practicable procedure for the oncomiR application, the contents include clinical sampling for miRNA performance, clinical miRNA detection with their analyses and clinical employment including prediction of prognosis of tumor disease and prediction of response to chemotherapy, diagnosis of tumor classification from miRNA biomarkers and RNA therapy from the miRNA analysis. In final part, I will present challenges and future development based on the clinical “oncomiR”.

Last modified: 2018-07-11 14:06:55