EVALUATION OF COAGULATION PROFILE IN PATIENTS WITH PREGNANCY INDUCED HYPERTENSION IN PATIENTS ATTENDING A TERTIARY CARE HOSPITAL IN NORTH INDIA

Pregnancy induced hypertension (PIH) is one of the most common causes of both maternal and neonatal morbidity and associated with adverse pregnancy outcomes.Profound changes in coagulation and fibrinolytic system occur during normal pregnancy causing hypercoagulable state. Early identification of high risk women and monitoring derangements in their coagulation system are surely pivotal in the prevention of complications. Hence, this study was undertaken to compare the coagulation profile in pre-eclamptic and eclamptic patients with normotensive pregnant patients Hypertension is one of the common medical complications of pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. Hypertension is a sign of an underlying pathology which may be pre-existing or appear for the first time during pregnancy. Various haematological changes like numerical and functional platelet abnormalities, alteration in haemoglobin and erythrocyte parameters and hypercoagulable state may be seen. Aims and Objectives: Evaluation of coagulation profile in PIH. Materials and Methods: A one year study was carried in the department of gynaecology and obstetrics on 100 PIH cases. Coagulation profile (PT, aPTT, INR and D-dimer) was done in all cases and values were correlated with the severity of PIH. Results: Total of 100 cases were included in the study. 32 were mild GH, 17cases were severe GH, 35 cases were mild pre-eclampsia and 16cases were in severe pre-eclampsia group. Prolonged PT, aPTT and D-Dimer was seen in 15 cases, 42 cases and 38 cases respectively. In our study we observed increased mean aPTT of 31.61+-2.89 and increased D-Dimer of 0.34?0.31 in severe pre-eclampsia patients. Hence we emphasize that raised aPTT, D-Dimer are alarming signs for aggressive treatment. Conclusion: Raised aPTT and D-dimer are fairly good indicator of severe pre-eclampsia and needs aggressive treatment.