ACINETOBACTER BAUMANNII: PREVALENCE, SPECTRUM AND DYNAMICS OF ANTIMICROBIAL RESISTANCE, SUSCEPTIBILITY TO ANTIBIOTIC COMBINATIONS

Objective. To study the spectrum and dynamics of antimicrobial resistance to Acinetobacter baumannii, to assess the resistance mechanisms to carbapenems and antibiotic combinations susceptibility. Material and Methods. The antibiotic susceptibility of 305 A.baumannii clinical isolates was determined by an automated method. Carbapenemase genes detection was performed by real-time PCR method. Multiple combination bactericidal testing method is used for determination of antibiotic combinations susceptibility. Conclusions. The proportion of A.baumannii in the etiological structure of infectious pathology is increased. An increase in antimicrobial resistance was noted. The presence of OXA-40 carbapenemase genes was detected. No isolates resistant to colistin were found. Meropenem-colistin, amikacin-colistin and levofloxacin-colistin combinations were bactericidal for 100% of the isolates.