PREDICTION OF EFFICIENCY OF PYROGENAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C

Background. Patients with chronic hepatitis C (CHC) are at risk of developing liver cirrhosis and require adequate antifibrotic therapy. The objective of the study was to develop a method for predicting the response to antifibrotic therapy with pyrogenal in patients with recurrent CHC. Material and methods. Before the start of pyrogenal therapy pyrogenal test was performed in 36 patients with CHC, followed by evaluation of serum levels of taurine, gamma-aminobutyric acid, leucine, 3-methoxy-4-hydroxyphenylglycol and tryptophan by high-performance liquid chromatography. The patients underwent a course of antifibrotic therapy with pyrogenal, the dynamics of fibrosis was assessed by the serum TIMP-1 values. Results. The equation of logistic regression for predicting the effectiveness of antifibrotic therapy of CHC with a binary response from the communication probit functions was constructed. The model predicts a positive or negative dynamics of the serum level of TIMP-1 after pyrogenal therapy. Conclusion. To predict the response to antifibrotic therapy with pyrogenal in patients with CHC, it is recommended that this model be used in conjunction with the model predicting the dynamics of the APRI index.