The ligand-receptor interaction in tinea pedis with allergid

Modern studies of various systems of the human body show the extreme importance of the ligand-receptor binding under physiological conditions as well as the development of pathological states. List of ligands is constantly expanding and today we found out a number of new mechanisms where their violation may play a role, including ? in the pathology of the skin. Aim of this study was to determine the functional state of the ligand-receptor interactions of bioelements and enzymes of lipid peroxidation (LPO) in patients without evidence of tinea pedis and various manifestations allergid skin. The study of complex clinical and laboratory methods 80 miners coal mines that have suffered tinea pedis than 1 year. Diagnosis of foot mycosis patients confirmed bacterioscopic and bacteriological methods. In order to establish the ligand-receptor interactions between the bioelements and enzymes responsible for the LPO have used techniques of atomic emission spectral analysis of the content of bioelements (hair) and biochemical studies in blood main regulatory enzymes of lipid peroxidation (using spectrophotometry). Statistical analysis was performed using licensed software package ?STATISTICA ® for Windows 6.0?. Patients with uncomplicated forms of mycosis (tinea) still found unreliable (p> 0.05) reduce the amount of hair bioelements such as Cu, Se, Zn, Co and Fe; in the presence of microbial eczema, allegrides and these changes (deficit) were significant (p < 0.05-0.001) compared with reference values; changes in blood lipid peroxidation enzymes (levels of diene conjugates and malondialdehyde) were opposite direction (significant increase; p< 0.05). The data on the presence of simultaneous changes of bioelements and enzymes in patients with mycosis POL stop support the view that the violation of ligand-receptor bonds (in the case of bioelements and relations enzymes) under the action of a complex of unfavorable factors (in particular ? high temperature, humidity and other) cause damage to the cells of the human body. This gives grounds for an integrated approach to treatment and dispensary patients with tinea pedis activities if they work in hazardous conditions (miners).