Pseudomembranous Candidiasis Indicates High Level Drug Resistance among Patients on Antiretroviral Treatment in Nairobi East District, Kenya
Journal: Journal of HIV for Clinical and Scientific Research (Vol.2, No. 2)Publication Date: 2015-09-25
Authors : Koyio LN van der Sanden WJM Jan Mulder Dimba EO Creugers NHJ Merkx TMAW Stelma FF; van der Ven Andre JAM;
Page : 040-044
Keywords : HIV; Oropharyngeal candidiasis; ART; Drug resistance; Kenya;
Abstract
Objectives: The aim of this study was to determine antiretroviral drug resistance patterns in patients on long-term antiretroviral therapy presenting with OPC.
Methods: An exploratory survey was performed among HIV-infected patients on ART for minimum of 24 months presenting with OPC in Nairobi, Kenya. Type (pseudomembraneous or erythematous candidiasis, angular cheilitis) and previous episodes of OPC, CD4-cell counts, duration, regimen and adherence on ART were compared between patients with high (>1000copies/ml) and low HIV-RNA levels. Genotypic resistance testing was performed on those with high viral loads.
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