CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF THE SKIN IN CHILDREN WITH ATOPIC DERMATITIS

Background. Atopic dermatitis (AD) is an actual problem of pediatrics due to its wide prevalence. The aim is to give clinical and morphological characteristic of the skin in children with AD and reveal its relationship with clinical manifestations. Material and methods. Morphological and immunohistochemical study of 27 biopsies of atopic and 48 biopsies of non-atopic skin was carried out. Results. Expression of IgE and CD8 in the epidermis is a favorable sign, since the intensity of itching and the area of skin lesions is less (p=0.03 in both cases). 100% of samples of the erythematous-squamous form were infiltrated with CD4+ in derma, which is more common than in other clinical forms (p=0.01). The dynamics of the SCORAD was greater in children without infiltration of CD4 cells in the epidermis (p=0.04) due to the higher initial amount of SCORAD points (p=0.02). Conclusions. Morphological and immunohistochemical markers are significantly associated with clinical features of AD.