STATE OF URINARY TRACTS’IMMUNITYINPATIENTS WITH ACUTE PYELONEPHRITIS AND CYSTITIS

Materials and methods. 64 patients with acute pyelonephritis (AP) and 15 healthy women were examined. in urine were determined indices which characterized a state of urinary tracts' immunity. The analysis of immunological data of urine was carry out in patients with AP (first detected) and by exacerbation chronic pyelonephritis with concomitant cystitis (acute or chronic) or without him. Results. in urine of AP patients were marked useful increase of levels of many immunological indices – complement's C3–component, lactoferrin, lisozym, myeloperoxidasa, immunoglobulins A, М, G, secretory igA (sigA), secretory component (SC) and cytokine's disbalans TNF– a and iL–10 with predomination of proinflammatory cytokines. Conclusions. in urine of patients with AP and cystitis observed the greatest elevation of above–mentioned indices levels except igA, sigA and SC level. The reliable differences between the groups of patients with AP with concomitant acute or chronic cystitis don't showed save the igM level which reliable rised in patients with acute cystitis.