PYRAMIDAL LAYER THINNING, SHRUNKEN NEURONS AND DEEP VACUOLATION IN HIPPOCAMPUS DUE TO THE ORGANIC LEAD INDUCED TOXICITY

Lead, a known heavy metal exerts its toxicity on different organ systems of which the neurotoxicity is a considered to a significant consequence. The organic lead exposure on the hippocampus, that plays a significant role in the formation of short and long term memory, navigation and also participates in the limbic system in the brain, was studied. The resulting effects were the thinning of neuron layers, vacuolation and reduction in overall cell population of neurons, thereby showing the primary effect on the pyramidal layers of the hippocampus.