Clozapine re-challenge in patients with history of blood dyscrasia 3 Year follow up

Clozapine re-challenge in an individual with a history of clozapine-induced blood dyscrasia is not often attempted. However it can be considered in patients with history of good response to the drug in the past, and where the risk of re-challenge is considered to be less than the risk of withholding treatment. Increasing the frequency of monitoring of white blood counts and the use of lithium or Granulocyte-Colony Stimulating Factors are the strategies that have been reported to be helpful during re-challenge. A dyscrasia that occurs during rechallenge is reported to be earlier in onset and longer lasting. We report the three year follow up data of two patients who had a blood dyscrasia following which they were re-challenged with clozapine